GrippeFranceV1, Main, Exploration, bibRecord, 000131

Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential.

Identifieur interne : 000131 ( Main/Exploration ); précédent : 000130; suivant : 000132

Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential.

Auteurs : François-Xavier Briand [France] ; Audrey Schmitz [France] ; Katell Ogor [France] ; Aurélie Le Prioux [France] ; Cécile Guillou-Cloarec [France] ; Carole Guillemoto [France] ; Chantal Allée [France] ; Marie-Odile Le Bras [France] ; Edouard Hirchaud [France] ; Hélène Quenault [France] ; Fabrice Touzain [France] ; Martine Cherbonnel-Pansart [France] ; Evelyne Lemaitre [France] ; Céline Courtillon [France] ; Hélène Gares [France] ; Patrick Daniel [France] ; Alexandre Fediaevsky [France] ; Pascale Massin [France] ; Yannick Blanchard [France] ; Nicolas Eterradossi [France] ; Sylvie Van Der Werf [France] ; Véronique Jestin [France] ; Eric Niqueux [France]

Source :

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [ 1560-7917 ] ; 2017.

RBID : pubmed:28277218

Descripteurs français

English descriptors

KwdEn :
- Animals (MeSH), Birds (MeSH), Chickens (MeSH), Disease Outbreaks (MeSH), Ducks (MeSH), France (epidemiology), Genes, Viral (genetics), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Humans (MeSH), Influenza A Virus, H5N1 Subtype (classification), Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (isolation & purification), Influenza A Virus, H5N1 Subtype (pathogenicity), Influenza A Virus, H5N2 Subtype (classification), Influenza A Virus, H5N2 Subtype (genetics), Influenza A Virus, H5N2 Subtype (isolation & purification), Influenza A Virus, H5N2 Subtype (pathogenicity), Influenza in Birds (epidemiology), Influenza in Birds (virology), Molecular Sequence Data (MeSH), Phylogeny (MeSH), Polymerase Chain Reaction (MeSH), Poultry (virology), Poultry Diseases (virology), RNA, Viral (genetics), Sequence Analysis, DNA (MeSH).
MESH :
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, RNA, Viral.
- classification : Influenza A Virus, H5N1 Subtype, Influenza A Virus, H5N2 Subtype.
- epidemiology : France, Influenza in Birds.
- genetics : Genes, Viral, Influenza A Virus, H5N1 Subtype, Influenza A Virus, H5N2 Subtype.
- isolation & purification : Influenza A Virus, H5N1 Subtype, Influenza A Virus, H5N2 Subtype.
- pathogenicity : Influenza A Virus, H5N1 Subtype, Influenza A Virus, H5N2 Subtype.
- virology : Influenza in Birds, Poultry, Poultry Diseases.
- Animals, Birds, Chickens, Disease Outbreaks, Ducks, Humans, Molecular Sequence Data, Phylogeny, Polymerase Chain Reaction, Sequence Analysis, DNA.

Abstract

Several new highly pathogenic (HP) H5 avian influenza virus (AIV) have been detected in poultry farms from south-western France since November 2015, among which an HP H5N1. The zoonotic potential and origin of these AIVs immediately became matters of concern. One virus of each subtype H5N1 (150169a), H5N2 (150233) and H5N9 (150236) was characterised. All proved highly pathogenic for poultry as demonstrated molecularly by the presence of a polybasic cleavage site in their HA protein - with a sequence (HQRRKR/GLF) previously unknown among avian H5 HPAI viruses - or experimentally by the in vivo demonstration of an intravenous pathogenicity index of 2.9 for the H5N1 HP isolate. Phylogenetic analyses based on the full genomes obtained by NGS confirmed that the eight viral segments of the three isolates were all part of avian Eurasian phylogenetic lineage but differed from the Gs/Gd/1/96-like lineage. The study of the genetic characteristics at specific amino acid positions relevant for modulating the adaptation to and the virulence for mammals showed that presently, these viruses possess most molecular features characteristic of AIV and lack some major characteristics required for efficient respiratory transmission to or between humans. The three isolates are therefore predicted to have no significant pandemic potential.

DOI: 10.2807/1560-7917.ES.2017.22.9.30473
PubMed: 28277218
PubMed Central: PMC5356430

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000122
to stream Main, to step Curation: 000122

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential.</title>
<author><name sortKey="Briand, Francois Xavier" sort="Briand, Francois Xavier" uniqKey="Briand F" first="François-Xavier" last="Briand">François-Xavier Briand</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmitz, Audrey" sort="Schmitz, Audrey" uniqKey="Schmitz A" first="Audrey" last="Schmitz">Audrey Schmitz</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ogor, Katell" sort="Ogor, Katell" uniqKey="Ogor K" first="Katell" last="Ogor">Katell Ogor</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Prioux, Aurelie" sort="Le Prioux, Aurelie" uniqKey="Le Prioux A" first="Aurélie" last="Le Prioux">Aurélie Le Prioux</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guillou Cloarec, Cecile" sort="Guillou Cloarec, Cecile" uniqKey="Guillou Cloarec C" first="Cécile" last="Guillou-Cloarec">Cécile Guillou-Cloarec</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guillemoto, Carole" sort="Guillemoto, Carole" uniqKey="Guillemoto C" first="Carole" last="Guillemoto">Carole Guillemoto</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Allee, Chantal" sort="Allee, Chantal" uniqKey="Allee C" first="Chantal" last="Allée">Chantal Allée</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Bras, Marie Odile" sort="Le Bras, Marie Odile" uniqKey="Le Bras M" first="Marie-Odile" last="Le Bras">Marie-Odile Le Bras</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hirchaud, Edouard" sort="Hirchaud, Edouard" uniqKey="Hirchaud E" first="Edouard" last="Hirchaud">Edouard Hirchaud</name>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité Génétique Virale et Biosécurité, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité Génétique Virale et Biosécurité, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Quenault, Helene" sort="Quenault, Helene" uniqKey="Quenault H" first="Hélène" last="Quenault">Hélène Quenault</name>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité Génétique Virale et Biosécurité, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité Génétique Virale et Biosécurité, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Touzain, Fabrice" sort="Touzain, Fabrice" uniqKey="Touzain F" first="Fabrice" last="Touzain">Fabrice Touzain</name>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité Génétique Virale et Biosécurité, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité Génétique Virale et Biosécurité, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cherbonnel Pansart, Martine" sort="Cherbonnel Pansart, Martine" uniqKey="Cherbonnel Pansart M" first="Martine" last="Cherbonnel-Pansart">Martine Cherbonnel-Pansart</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lemaitre, Evelyne" sort="Lemaitre, Evelyne" uniqKey="Lemaitre E" first="Evelyne" last="Lemaitre">Evelyne Lemaitre</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Courtillon, Celine" sort="Courtillon, Celine" uniqKey="Courtillon C" first="Céline" last="Courtillon">Céline Courtillon</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gares, Helene" sort="Gares, Helene" uniqKey="Gares H" first="Hélène" last="Gares">Hélène Gares</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire Départemental d'Analyses et de Recherche, Coulounieix Chamiers, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Départemental d'Analyses et de Recherche, Coulounieix Chamiers</wicri:regionArea>
<wicri:noRegion>Coulounieix Chamiers</wicri:noRegion>
<wicri:noRegion>Coulounieix Chamiers</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Daniel, Patrick" sort="Daniel, Patrick" uniqKey="Daniel P" first="Patrick" last="Daniel">Patrick Daniel</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire des Pyrénées et des Landes, Mont-de-Marsan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire des Pyrénées et des Landes, Mont-de-Marsan</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Mont-de-Marsan</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fediaevsky, Alexandre" sort="Fediaevsky, Alexandre" uniqKey="Fediaevsky A" first="Alexandre" last="Fediaevsky">Alexandre Fediaevsky</name>
<affiliation wicri:level="3"><nlm:affiliation>Direction Générale de l'Alimentation - MAAF, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Direction Générale de l'Alimentation - MAAF, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Massin, Pascale" sort="Massin, Pascale" uniqKey="Massin P" first="Pascale" last="Massin">Pascale Massin</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blanchard, Yannick" sort="Blanchard, Yannick" uniqKey="Blanchard Y" first="Yannick" last="Blanchard">Yannick Blanchard</name>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité Génétique Virale et Biosécurité, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité Génétique Virale et Biosécurité, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eterradossi, Nicolas" sort="Eterradossi, Nicolas" uniqKey="Eterradossi N" first="Nicolas" last="Eterradossi">Nicolas Eterradossi</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Pasteur, Unité Génétique Moléculaire des Virus à ARN - CNR grippe, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur, Unité Génétique Moléculaire des Virus à ARN - CNR grippe, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Anses - Groupe d'Experts Spécialisé Santé Animale et Bien-être Animal, Maisons-Alfort, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses - Groupe d'Experts Spécialisé Santé Animale et Bien-être Animal, Maisons-Alfort</wicri:regionArea>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jestin, Veronique" sort="Jestin, Veronique" uniqKey="Jestin V" first="Véronique" last="Jestin">Véronique Jestin</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses - Groupe d'Experts Spécialisé Santé Animale et Bien-être Animal, Maisons-Alfort, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses - Groupe d'Experts Spécialisé Santé Animale et Bien-être Animal, Maisons-Alfort</wicri:regionArea>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niqueux, Eric" sort="Niqueux, Eric" uniqKey="Niqueux E" first="Eric" last="Niqueux">Eric Niqueux</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28277218</idno>
<idno type="pmid">28277218</idno>
<idno type="doi">10.2807/1560-7917.ES.2017.22.9.30473</idno>
<idno type="pmc">PMC5356430</idno>
<idno type="wicri:Area/Main/Corpus">000122</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000122</idno>
<idno type="wicri:Area/Main/Curation">000122</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000122</idno>
<idno type="wicri:Area/Main/Exploration">000122</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential.</title>
<author><name sortKey="Briand, Francois Xavier" sort="Briand, Francois Xavier" uniqKey="Briand F" first="François-Xavier" last="Briand">François-Xavier Briand</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmitz, Audrey" sort="Schmitz, Audrey" uniqKey="Schmitz A" first="Audrey" last="Schmitz">Audrey Schmitz</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ogor, Katell" sort="Ogor, Katell" uniqKey="Ogor K" first="Katell" last="Ogor">Katell Ogor</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Prioux, Aurelie" sort="Le Prioux, Aurelie" uniqKey="Le Prioux A" first="Aurélie" last="Le Prioux">Aurélie Le Prioux</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guillou Cloarec, Cecile" sort="Guillou Cloarec, Cecile" uniqKey="Guillou Cloarec C" first="Cécile" last="Guillou-Cloarec">Cécile Guillou-Cloarec</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guillemoto, Carole" sort="Guillemoto, Carole" uniqKey="Guillemoto C" first="Carole" last="Guillemoto">Carole Guillemoto</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Allee, Chantal" sort="Allee, Chantal" uniqKey="Allee C" first="Chantal" last="Allée">Chantal Allée</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Bras, Marie Odile" sort="Le Bras, Marie Odile" uniqKey="Le Bras M" first="Marie-Odile" last="Le Bras">Marie-Odile Le Bras</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hirchaud, Edouard" sort="Hirchaud, Edouard" uniqKey="Hirchaud E" first="Edouard" last="Hirchaud">Edouard Hirchaud</name>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité Génétique Virale et Biosécurité, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité Génétique Virale et Biosécurité, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Quenault, Helene" sort="Quenault, Helene" uniqKey="Quenault H" first="Hélène" last="Quenault">Hélène Quenault</name>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité Génétique Virale et Biosécurité, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité Génétique Virale et Biosécurité, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Touzain, Fabrice" sort="Touzain, Fabrice" uniqKey="Touzain F" first="Fabrice" last="Touzain">Fabrice Touzain</name>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité Génétique Virale et Biosécurité, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité Génétique Virale et Biosécurité, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cherbonnel Pansart, Martine" sort="Cherbonnel Pansart, Martine" uniqKey="Cherbonnel Pansart M" first="Martine" last="Cherbonnel-Pansart">Martine Cherbonnel-Pansart</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lemaitre, Evelyne" sort="Lemaitre, Evelyne" uniqKey="Lemaitre E" first="Evelyne" last="Lemaitre">Evelyne Lemaitre</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Courtillon, Celine" sort="Courtillon, Celine" uniqKey="Courtillon C" first="Céline" last="Courtillon">Céline Courtillon</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gares, Helene" sort="Gares, Helene" uniqKey="Gares H" first="Hélène" last="Gares">Hélène Gares</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire Départemental d'Analyses et de Recherche, Coulounieix Chamiers, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Départemental d'Analyses et de Recherche, Coulounieix Chamiers</wicri:regionArea>
<wicri:noRegion>Coulounieix Chamiers</wicri:noRegion>
<wicri:noRegion>Coulounieix Chamiers</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Daniel, Patrick" sort="Daniel, Patrick" uniqKey="Daniel P" first="Patrick" last="Daniel">Patrick Daniel</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire des Pyrénées et des Landes, Mont-de-Marsan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire des Pyrénées et des Landes, Mont-de-Marsan</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Mont-de-Marsan</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fediaevsky, Alexandre" sort="Fediaevsky, Alexandre" uniqKey="Fediaevsky A" first="Alexandre" last="Fediaevsky">Alexandre Fediaevsky</name>
<affiliation wicri:level="3"><nlm:affiliation>Direction Générale de l'Alimentation - MAAF, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Direction Générale de l'Alimentation - MAAF, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Massin, Pascale" sort="Massin, Pascale" uniqKey="Massin P" first="Pascale" last="Massin">Pascale Massin</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blanchard, Yannick" sort="Blanchard, Yannick" uniqKey="Blanchard Y" first="Yannick" last="Blanchard">Yannick Blanchard</name>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité Génétique Virale et Biosécurité, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité Génétique Virale et Biosécurité, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eterradossi, Nicolas" sort="Eterradossi, Nicolas" uniqKey="Eterradossi N" first="Nicolas" last="Eterradossi">Nicolas Eterradossi</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Pasteur, Unité Génétique Moléculaire des Virus à ARN - CNR grippe, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur, Unité Génétique Moléculaire des Virus à ARN - CNR grippe, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Anses - Groupe d'Experts Spécialisé Santé Animale et Bien-être Animal, Maisons-Alfort, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses - Groupe d'Experts Spécialisé Santé Animale et Bien-être Animal, Maisons-Alfort</wicri:regionArea>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jestin, Veronique" sort="Jestin, Veronique" uniqKey="Jestin V" first="Véronique" last="Jestin">Véronique Jestin</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses - Groupe d'Experts Spécialisé Santé Animale et Bien-être Animal, Maisons-Alfort, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses - Groupe d'Experts Spécialisé Santé Animale et Bien-être Animal, Maisons-Alfort</wicri:regionArea>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niqueux, Eric" sort="Niqueux, Eric" uniqKey="Niqueux E" first="Eric" last="Niqueux">Eric Niqueux</name>
<affiliation wicri:level="1"><nlm:affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan</wicri:regionArea>
<wicri:noRegion>Ploufragan</wicri:noRegion>
<wicri:noRegion>Ploufragan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université Bretagne-Loire, Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bretagne-Loire, Rennes</wicri:regionArea>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</title>
<idno type="eISSN">1560-7917</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Birds (MeSH)</term>
<term>Chickens (MeSH)</term>
<term>Disease Outbreaks (MeSH)</term>
<term>Ducks (MeSH)</term>
<term>France (epidemiology)</term>
<term>Genes, Viral (genetics)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term>
<term>Humans (MeSH)</term>
<term>Influenza A Virus, H5N1 Subtype (classification)</term>
<term>Influenza A Virus, H5N1 Subtype (genetics)</term>
<term>Influenza A Virus, H5N1 Subtype (isolation & purification)</term>
<term>Influenza A Virus, H5N1 Subtype (pathogenicity)</term>
<term>Influenza A Virus, H5N2 Subtype (classification)</term>
<term>Influenza A Virus, H5N2 Subtype (genetics)</term>
<term>Influenza A Virus, H5N2 Subtype (isolation & purification)</term>
<term>Influenza A Virus, H5N2 Subtype (pathogenicity)</term>
<term>Influenza in Birds (epidemiology)</term>
<term>Influenza in Birds (virology)</term>
<term>Molecular Sequence Data (MeSH)</term>
<term>Phylogeny (MeSH)</term>
<term>Polymerase Chain Reaction (MeSH)</term>
<term>Poultry (virology)</term>
<term>Poultry Diseases (virology)</term>
<term>RNA, Viral (genetics)</term>
<term>Sequence Analysis, DNA (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term>
<term>Analyse de séquence d'ADN (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Canards (MeSH)</term>
<term>Données de séquences moléculaires (MeSH)</term>
<term>France (épidémiologie)</term>
<term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term>
<term>Grippe chez les oiseaux (virologie)</term>
<term>Grippe chez les oiseaux (épidémiologie)</term>
<term>Gènes viraux (génétique)</term>
<term>Humains (MeSH)</term>
<term>Maladies de la volaille (virologie)</term>
<term>Oiseaux (MeSH)</term>
<term>Phylogenèse (MeSH)</term>
<term>Poulets (MeSH)</term>
<term>Réaction de polymérisation en chaîne (MeSH)</term>
<term>Sous-type H5N1 du virus de la grippe A (classification)</term>
<term>Sous-type H5N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H5N1 du virus de la grippe A (isolement et purification)</term>
<term>Sous-type H5N1 du virus de la grippe A (pathogénicité)</term>
<term>Sous-type H5N2 du virus de la grippe A (classification)</term>
<term>Sous-type H5N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H5N2 du virus de la grippe A (isolement et purification)</term>
<term>Sous-type H5N2 du virus de la grippe A (pathogénicité)</term>
<term>Volaille (virologie)</term>
<term>Épidémies de maladies (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza A Virus, H5N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>France</term>
<term>Influenza in Birds</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genes, Viral</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza A Virus, H5N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Gènes viraux</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Sous-type H5N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza A Virus, H5N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term>
<term>Sous-type H5N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza A Virus, H5N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term>
<term>Sous-type H5N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term>
<term>Maladies de la volaille</term>
<term>Volaille</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term>
<term>Poultry</term>
<term>Poultry Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>France</term>
<term>Grippe chez les oiseaux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Birds</term>
<term>Chickens</term>
<term>Disease Outbreaks</term>
<term>Ducks</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Polymerase Chain Reaction</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ADN</term>
<term>Animaux</term>
<term>Canards</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Oiseaux</term>
<term>Phylogenèse</term>
<term>Poulets</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Épidémies de maladies</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Several new highly pathogenic (HP) H5 avian influenza virus (AIV) have been detected in poultry farms from south-western France since November 2015, among which an HP H5N1. The zoonotic potential and origin of these AIVs immediately became matters of concern. One virus of each subtype H5N1 (150169a), H5N2 (150233) and H5N9 (150236) was characterised. All proved highly pathogenic for poultry as demonstrated molecularly by the presence of a polybasic cleavage site in their HA protein - with a sequence (HQRRKR/GLF) previously unknown among avian H5 HPAI viruses - or experimentally by the in vivo demonstration of an intravenous pathogenicity index of 2.9 for the H5N1 HP isolate. Phylogenetic analyses based on the full genomes obtained by NGS confirmed that the eight viral segments of the three isolates were all part of avian Eurasian phylogenetic lineage but differed from the Gs/Gd/1/96-like lineage. The study of the genetic characteristics at specific amino acid positions relevant for modulating the adaptation to and the virulence for mammals showed that presently, these viruses possess most molecular features characteristic of AIV and lack some major characteristics required for efficient respiratory transmission to or between humans. The three isolates are therefore predicted to have no significant pandemic potential.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28277218</PMID>
<DateCompleted><Year>2017</Year>
<Month>05</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1560-7917</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>22</Volume>
<Issue>9</Issue>
<PubDate><Year>2017</Year>
<Month>Mar</Month>
<Day>02</Day>
</PubDate>
</JournalIssue>
<Title>Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</Title>
<ISOAbbreviation>Euro Surveill.</ISOAbbreviation>
</Journal>
<ArticleTitle>Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential.</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.2807/1560-7917.ES.2017.22.9.30473</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">30473</ELocationID>
<Abstract><AbstractText>Several new highly pathogenic (HP) H5 avian influenza virus (AIV) have been detected in poultry farms from south-western France since November 2015, among which an HP H5N1. The zoonotic potential and origin of these AIVs immediately became matters of concern. One virus of each subtype H5N1 (150169a), H5N2 (150233) and H5N9 (150236) was characterised. All proved highly pathogenic for poultry as demonstrated molecularly by the presence of a polybasic cleavage site in their HA protein - with a sequence (HQRRKR/GLF) previously unknown among avian H5 HPAI viruses - or experimentally by the in vivo demonstration of an intravenous pathogenicity index of 2.9 for the H5N1 HP isolate. Phylogenetic analyses based on the full genomes obtained by NGS confirmed that the eight viral segments of the three isolates were all part of avian Eurasian phylogenetic lineage but differed from the Gs/Gd/1/96-like lineage. The study of the genetic characteristics at specific amino acid positions relevant for modulating the adaptation to and the virulence for mammals showed that presently, these viruses possess most molecular features characteristic of AIV and lack some major characteristics required for efficient respiratory transmission to or between humans. The three isolates are therefore predicted to have no significant pandemic potential.</AbstractText>
<CopyrightInformation>This article is copyright of The Authors, 2017.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Briand</LastName>
<ForeName>François-Xavier</ForeName>
<Initials>FX</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schmitz</LastName>
<ForeName>Audrey</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ogor</LastName>
<ForeName>Katell</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Le Prioux</LastName>
<ForeName>Aurélie</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guillou-Cloarec</LastName>
<ForeName>Cécile</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guillemoto</LastName>
<ForeName>Carole</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Allée</LastName>
<ForeName>Chantal</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Le Bras</LastName>
<ForeName>Marie-Odile</ForeName>
<Initials>MO</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hirchaud</LastName>
<ForeName>Edouard</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Anses, Unité Génétique Virale et Biosécurité, Ploufragan, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Quenault</LastName>
<ForeName>Hélène</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Anses, Unité Génétique Virale et Biosécurité, Ploufragan, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Touzain</LastName>
<ForeName>Fabrice</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Anses, Unité Génétique Virale et Biosécurité, Ploufragan, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cherbonnel-Pansart</LastName>
<ForeName>Martine</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lemaitre</LastName>
<ForeName>Evelyne</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Courtillon</LastName>
<ForeName>Céline</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gares</LastName>
<ForeName>Hélène</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Laboratoire Départemental d'Analyses et de Recherche, Coulounieix Chamiers, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Daniel</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Laboratoire des Pyrénées et des Landes, Mont-de-Marsan, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fediaevsky</LastName>
<ForeName>Alexandre</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Direction Générale de l'Alimentation - MAAF, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Massin</LastName>
<ForeName>Pascale</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blanchard</LastName>
<ForeName>Yannick</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Anses, Unité Génétique Virale et Biosécurité, Ploufragan, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eterradossi</LastName>
<ForeName>Nicolas</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van der Werf</LastName>
<ForeName>Sylvie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institut Pasteur, Unité Génétique Moléculaire des Virus à ARN - CNR grippe, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Anses - Groupe d'Experts Spécialisé Santé Animale et Bien-être Animal, Maisons-Alfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jestin</LastName>
<ForeName>Véronique</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Anses - Groupe d'Experts Spécialisé Santé Animale et Bien-être Animal, Maisons-Alfort, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Niqueux</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Anses, Unité VIPAC - LNR influenza aviaire, Ploufragan, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Bretagne-Loire, Rennes, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Sweden</Country>
<MedlineTA>Euro Surveill</MedlineTA>
<NlmUniqueID>100887452</NlmUniqueID>
<ISSNLinking>1025-496X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001717" MajorTopicYN="N">Birds</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002645" MajorTopicYN="N">Chickens</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004372" MajorTopicYN="N">Ducks</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N">France</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005814" MajorTopicYN="N">Genes, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053124" MajorTopicYN="N">Influenza A Virus, H5N1 Subtype</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053125" MajorTopicYN="N">Influenza A Virus, H5N2 Subtype</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011200" MajorTopicYN="N">Poultry</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011201" MajorTopicYN="N">Poultry Diseases</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Avian influenza</Keyword>
<Keyword MajorTopicYN="N">H5</Keyword>
<Keyword MajorTopicYN="N">Zoonotic Potential</Keyword>
<Keyword MajorTopicYN="N">highly pathogenic</Keyword>
<Keyword MajorTopicYN="N">phylogeny</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>03</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>08</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>3</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>3</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>5</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28277218</ArticleId>
<ArticleId IdType="doi">10.2807/1560-7917.ES.2017.22.9.30473</ArticleId>
<ArticleId IdType="pii">30473</ArticleId>
<ArticleId IdType="pmc">PMC5356430</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Virology. 2015 May;479-480:234-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25812763</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2008 Jan;82(2):596-601</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17942553</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2013 Mar;9(3):e1003223</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23516363</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2009 Feb;47(2):327-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19052173</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2015 Apr;21(4):720-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25811303</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Avian Pathol. 2008 Feb;37(1):15-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18202945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Top Microbiol Immunol. 2014;385:137-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25048542</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Genet Evol. 2010 Oct;10(7):1075-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20624487</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 2013 Dec;30(12):2725-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24132122</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2015 Nov 2;209:23-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25916175</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2012 Dec;86(24):13879</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23166273</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Influenza Other Respir Viruses. 2015 Sep;9(5):271-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25966311</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2014 Apr 10;157(2):329-39</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24725402</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2010 Apr;91(Pt 4):960-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20016038</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2012 May 02;486(7403):420-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22722205</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2002 Sep;40(9):3256-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12202562</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Oct;20(10):1745-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25271444</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vet Microbiol. 2008 Apr 30;128(3-4):243-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18031958</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Avian Dis. 2007 Mar;51(1 Suppl):408-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17494595</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Avian Dis. 2007 Mar;51(1 Suppl):227-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17494558</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Wkly Epidemiol Rec. 2015 Mar 20;90(12):109-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25796641</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Wildl Dis. 2008 Oct;44(4):811-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18957637</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Aquitaine</li>
<li>Nouvelle-Aquitaine</li>
<li>Région Bretagne</li>
<li>Île-de-France</li>
</region>
<settlement><li>Mont-de-Marsan</li>
<li>Paris</li>
<li>Rennes</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Briand, Francois Xavier" sort="Briand, Francois Xavier" uniqKey="Briand F" first="François-Xavier" last="Briand">François-Xavier Briand</name>
</noRegion>
<name sortKey="Allee, Chantal" sort="Allee, Chantal" uniqKey="Allee C" first="Chantal" last="Allée">Chantal Allée</name>
<name sortKey="Allee, Chantal" sort="Allee, Chantal" uniqKey="Allee C" first="Chantal" last="Allée">Chantal Allée</name>
<name sortKey="Blanchard, Yannick" sort="Blanchard, Yannick" uniqKey="Blanchard Y" first="Yannick" last="Blanchard">Yannick Blanchard</name>
<name sortKey="Blanchard, Yannick" sort="Blanchard, Yannick" uniqKey="Blanchard Y" first="Yannick" last="Blanchard">Yannick Blanchard</name>
<name sortKey="Briand, Francois Xavier" sort="Briand, Francois Xavier" uniqKey="Briand F" first="François-Xavier" last="Briand">François-Xavier Briand</name>
<name sortKey="Cherbonnel Pansart, Martine" sort="Cherbonnel Pansart, Martine" uniqKey="Cherbonnel Pansart M" first="Martine" last="Cherbonnel-Pansart">Martine Cherbonnel-Pansart</name>
<name sortKey="Cherbonnel Pansart, Martine" sort="Cherbonnel Pansart, Martine" uniqKey="Cherbonnel Pansart M" first="Martine" last="Cherbonnel-Pansart">Martine Cherbonnel-Pansart</name>
<name sortKey="Courtillon, Celine" sort="Courtillon, Celine" uniqKey="Courtillon C" first="Céline" last="Courtillon">Céline Courtillon</name>
<name sortKey="Courtillon, Celine" sort="Courtillon, Celine" uniqKey="Courtillon C" first="Céline" last="Courtillon">Céline Courtillon</name>
<name sortKey="Daniel, Patrick" sort="Daniel, Patrick" uniqKey="Daniel P" first="Patrick" last="Daniel">Patrick Daniel</name>
<name sortKey="Eterradossi, Nicolas" sort="Eterradossi, Nicolas" uniqKey="Eterradossi N" first="Nicolas" last="Eterradossi">Nicolas Eterradossi</name>
<name sortKey="Eterradossi, Nicolas" sort="Eterradossi, Nicolas" uniqKey="Eterradossi N" first="Nicolas" last="Eterradossi">Nicolas Eterradossi</name>
<name sortKey="Fediaevsky, Alexandre" sort="Fediaevsky, Alexandre" uniqKey="Fediaevsky A" first="Alexandre" last="Fediaevsky">Alexandre Fediaevsky</name>
<name sortKey="Gares, Helene" sort="Gares, Helene" uniqKey="Gares H" first="Hélène" last="Gares">Hélène Gares</name>
<name sortKey="Guillemoto, Carole" sort="Guillemoto, Carole" uniqKey="Guillemoto C" first="Carole" last="Guillemoto">Carole Guillemoto</name>
<name sortKey="Guillemoto, Carole" sort="Guillemoto, Carole" uniqKey="Guillemoto C" first="Carole" last="Guillemoto">Carole Guillemoto</name>
<name sortKey="Guillou Cloarec, Cecile" sort="Guillou Cloarec, Cecile" uniqKey="Guillou Cloarec C" first="Cécile" last="Guillou-Cloarec">Cécile Guillou-Cloarec</name>
<name sortKey="Guillou Cloarec, Cecile" sort="Guillou Cloarec, Cecile" uniqKey="Guillou Cloarec C" first="Cécile" last="Guillou-Cloarec">Cécile Guillou-Cloarec</name>
<name sortKey="Hirchaud, Edouard" sort="Hirchaud, Edouard" uniqKey="Hirchaud E" first="Edouard" last="Hirchaud">Edouard Hirchaud</name>
<name sortKey="Hirchaud, Edouard" sort="Hirchaud, Edouard" uniqKey="Hirchaud E" first="Edouard" last="Hirchaud">Edouard Hirchaud</name>
<name sortKey="Jestin, Veronique" sort="Jestin, Veronique" uniqKey="Jestin V" first="Véronique" last="Jestin">Véronique Jestin</name>
<name sortKey="Le Bras, Marie Odile" sort="Le Bras, Marie Odile" uniqKey="Le Bras M" first="Marie-Odile" last="Le Bras">Marie-Odile Le Bras</name>
<name sortKey="Le Bras, Marie Odile" sort="Le Bras, Marie Odile" uniqKey="Le Bras M" first="Marie-Odile" last="Le Bras">Marie-Odile Le Bras</name>
<name sortKey="Le Prioux, Aurelie" sort="Le Prioux, Aurelie" uniqKey="Le Prioux A" first="Aurélie" last="Le Prioux">Aurélie Le Prioux</name>
<name sortKey="Le Prioux, Aurelie" sort="Le Prioux, Aurelie" uniqKey="Le Prioux A" first="Aurélie" last="Le Prioux">Aurélie Le Prioux</name>
<name sortKey="Lemaitre, Evelyne" sort="Lemaitre, Evelyne" uniqKey="Lemaitre E" first="Evelyne" last="Lemaitre">Evelyne Lemaitre</name>
<name sortKey="Lemaitre, Evelyne" sort="Lemaitre, Evelyne" uniqKey="Lemaitre E" first="Evelyne" last="Lemaitre">Evelyne Lemaitre</name>
<name sortKey="Massin, Pascale" sort="Massin, Pascale" uniqKey="Massin P" first="Pascale" last="Massin">Pascale Massin</name>
<name sortKey="Massin, Pascale" sort="Massin, Pascale" uniqKey="Massin P" first="Pascale" last="Massin">Pascale Massin</name>
<name sortKey="Niqueux, Eric" sort="Niqueux, Eric" uniqKey="Niqueux E" first="Eric" last="Niqueux">Eric Niqueux</name>
<name sortKey="Niqueux, Eric" sort="Niqueux, Eric" uniqKey="Niqueux E" first="Eric" last="Niqueux">Eric Niqueux</name>
<name sortKey="Ogor, Katell" sort="Ogor, Katell" uniqKey="Ogor K" first="Katell" last="Ogor">Katell Ogor</name>
<name sortKey="Ogor, Katell" sort="Ogor, Katell" uniqKey="Ogor K" first="Katell" last="Ogor">Katell Ogor</name>
<name sortKey="Quenault, Helene" sort="Quenault, Helene" uniqKey="Quenault H" first="Hélène" last="Quenault">Hélène Quenault</name>
<name sortKey="Quenault, Helene" sort="Quenault, Helene" uniqKey="Quenault H" first="Hélène" last="Quenault">Hélène Quenault</name>
<name sortKey="Schmitz, Audrey" sort="Schmitz, Audrey" uniqKey="Schmitz A" first="Audrey" last="Schmitz">Audrey Schmitz</name>
<name sortKey="Schmitz, Audrey" sort="Schmitz, Audrey" uniqKey="Schmitz A" first="Audrey" last="Schmitz">Audrey Schmitz</name>
<name sortKey="Touzain, Fabrice" sort="Touzain, Fabrice" uniqKey="Touzain F" first="Fabrice" last="Touzain">Fabrice Touzain</name>
<name sortKey="Touzain, Fabrice" sort="Touzain, Fabrice" uniqKey="Touzain F" first="Fabrice" last="Touzain">Fabrice Touzain</name>
<name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeFranceV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000131 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000131 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    GrippeFranceV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:28277218
   |texte=   Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:28277218" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a GrippeFranceV1

This area was generated with Dilib version V0.6.35.
Data generation: Sun Aug 9 07:31:43 2020. Site generation: Thu Mar 25 22:05:26 2021

	Serveur d'exploration sur la grippe en France
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la grippe en France

Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential.

Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki